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The other six responders also reported increased shedding without major hair loss.The Columbia team also performed gene expression profiling that showed that nonresponders had relatively low baseline expression of genes encoding interferon-gamma and cytotoxic T lymphocytes, which mediate type I cellular immunity and thereby help drive the pathogenesis of AA.There were no severe adverse effects, although nearly a third of patients developed upper respiratory tract infections.In another uncontrolled study of 13 patients with AA, totalis, or universalis, 9 (70%) patients achieved full regrowth and there were no serious adverse effects, although patients experienced headaches, upper respiratory infections, and mild increases in liver transaminase levels.She was lucky to have the support of her longtime girlfriend, who stayed with her throughout her transition — but not every trans person has a committed partner to give them love and acceptance regardless of gender identity.Unfortunately, there’s still a stigma working against trans men and women, especially in the romance department.By the end of treatment, seven of nine responders achieved more than 95% regrowth, one achieved 85% regrowth, and one achieved 55% regrowth.Importantly, none of these relatively healthy patients experienced serious adverse events on ruxolitinib, and none needed to stop treatment, although one patient experienced declining hemoglobin levels that resolved after dose modification.
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JAK inhibition also has a potential role for treating some scarring alopecias, including lichen planopilaris and frontal fibrosing alopecia.
These diseases are histologically “identical” and both exhibit perifollicular erythema, papules, and scale, all of which suggest active inflammation, Dr. Hair follicles from affected patients show immune markers such as interferon-inducible chemokines, cytotoxic T cell responses, and expression of major histocompatibility complexes I and II.
It was a shocking revelation to those of us who’d known a rowdy, raunchy frat boy in undergrad and suddenly saw the poised, purple-haired woman who’d been hiding for all those years.
My friend said coming out on Facebook was a liberating experience for her.